Zepbound® (tirzepatide) — 2.5 mg
- Commercial plan — denied or excluded
- Priced September 27, 2026
Your cheapest verified route right now
verified price- Per year at 12 fills
- $3,588
A plan exclusion is not the end. Under ACA rules you have 180 days to appeal, and secondary indications (sleep apnea for Zepbound, cardiovascular risk for Wegovy) run through different criteria. See your PBM's policy page.
Before your next appointment: at 5 mg your cheapest route (LillyDirect self-pay) goes to $399/month — $100/month more than your current dose. WalletNoise shows the cost of a dose change, never whether to make one — that's your prescriber's call. Verified Sep 5, 2026 ·lilly.com
Ramp cost calculator
CloseWhat the climb costs
12-month total $3,887 13 fills
Average per fill $299 peak $299
Flat at 2.5 mg $3,887 what multiplying today's price gives you
- 2.5 mg 13×
Every fill, dated and priced (13)
- 1 Sep 27, 2026 2.5 mg LillyDirect self-pay $299
- 2 Oct 25, 2026 2.5 mg LillyDirect self-pay $299
- 3 Nov 22, 2026 2.5 mg LillyDirect self-pay $299
- 4 Dec 20, 2026 2.5 mg LillyDirect self-pay $299
- 5 Jan 17, 2027 2.5 mg LillyDirect self-pay $299
- 6 Feb 14, 2027 2.5 mg LillyDirect self-pay $299
- 7 Mar 14, 2027 2.5 mg LillyDirect self-pay $299
- 8 Apr 11, 2027 2.5 mg LillyDirect self-pay $299
- 9 May 9, 2027 2.5 mg LillyDirect self-pay $299
- 10 Jun 6, 2027 2.5 mg LillyDirect self-pay $299
- 11 Jul 4, 2027 2.5 mg LillyDirect self-pay $299
- 12 Aug 1, 2027 2.5 mg LillyDirect self-pay $299
- 13 Aug 29, 2027 2.5 mg LillyDirect self-pay $299
This is arithmetic, not a plan. Fills are spaced 28 days apart — the label's own supply length — and priced on the date each one falls, so dated price changes are already included. Your prescriber decides whether you step at all, and many people stay at a lower dose.
The label's own words (once weekly)
Initiate at 2.5 mg once weekly for 4 weeks. After 4 weeks, increase to 5 mg once weekly. The dosage may be increased in 2.5 mg increments after at least 4 weeks on the current dosage. The 2.5 mg dosage is for initiation and is not approved as a maintenance dosage. Maximum 15 mg once weekly.
Verified Aug 31, 2026 ·pi.lilly.com
Every route we can price
Verified prices outrank cheaper estimates. Reference rows inform, never win.
- Rank 1
LillyDirect self-pay
$299/mo- Lilly's direct channel. Vial and KwikPen at identical self-pay prices at every tier. Telehealth not included.
Verified Sep 5, 2026 · lilly.com
- Rank 2
Discount card at retail (GoodRx and similar)
verify locally$299/mo- Dose- and pharmacy-dependent. Verify at your ZIP before relying on it.
Verified Aug 29, 2026 · goodrx.com
TrumpRx
reference verify locally$299/mo- Starting-at price; routes you to LillyDirect pricing tiers by dose
- Government referral site — does not sell drugs or process payments; issues coupons or routes to manufacturer DTC channels.
Verified Sep 2, 2026 · trumprx.gov
Retail list price (reference)
reference verify locally$1,087/mo- Cited to TrumpRx, which displays $1,087 as Zepbound's list price; drugs.com stopped publishing it and now shows the LillyDirect self-pay tiers instead
- Context anchor only — what the drug costs with no route at all. Walk-in cash at retail typically exceeds WAC.
Verified Sep 2, 2026 · trumprx.gov
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