in 4 days Aetna (CVS Health) — Zepbound back as additional preferred on templates See the changelog
WalletNoise

Zepbound® (tirzepatide) — 2.5 mg

Your cheapest verified route right now

verified price

$299 /month

LillyDirect self-pay

Verified Sep 5, 2026 · lilly.com

Per year at 12 fills
$3,588
Medicaid coverage of GLP-1s for obesity is state-by-state (13 states as of Jan 2026). See the Medicaid policy page for the current picture and your appeal rights.
Before your next appointment: at 5 mg your cheapest route (LillyDirect self-pay) goes to $399/month — $100/month more than your current dose. WalletNoise shows the cost of a dose change, never whether to make one — that's your prescriber's call. Verified Sep 5, 2026 ·lilly.com
Ramp cost calculator

What the climb costs

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Both doses are yours to state, not ours to suggest. WalletNoise prices the schedule you describe and never recommends a dose, a target, or a pace — that is your prescriber's call.

12-month total $3,887 13 fills
Average per fill $299 peak $299
Flat at 2.5 mg $3,887 what multiplying today's price gives you
Cost per fill, 2.5 mg to 2.5 mg
  • 2.5 mg 13×
$0 $150 $300 2.5 mg — $299 $299 Sep2.5 mg — $299 Oct2.5 mg — $299 Nov2.5 mg — $299 Dec2.5 mg — $299 Jan2.5 mg — $299 Feb2.5 mg — $299 Mar2.5 mg — $299 Apr2.5 mg — $299 May2.5 mg — $299 Jun2.5 mg — $299 Jul2.5 mg — $299 Aug2.5 mg — $299
Every fill, dated and priced (13)
  1. 1 Sep 27, 2026 2.5 mg LillyDirect self-pay $299
  2. 2 Oct 25, 2026 2.5 mg LillyDirect self-pay $299
  3. 3 Nov 22, 2026 2.5 mg LillyDirect self-pay $299
  4. 4 Dec 20, 2026 2.5 mg LillyDirect self-pay $299
  5. 5 Jan 17, 2027 2.5 mg LillyDirect self-pay $299
  6. 6 Feb 14, 2027 2.5 mg LillyDirect self-pay $299
  7. 7 Mar 14, 2027 2.5 mg LillyDirect self-pay $299
  8. 8 Apr 11, 2027 2.5 mg LillyDirect self-pay $299
  9. 9 May 9, 2027 2.5 mg LillyDirect self-pay $299
  10. 10 Jun 6, 2027 2.5 mg LillyDirect self-pay $299
  11. 11 Jul 4, 2027 2.5 mg LillyDirect self-pay $299
  12. 12 Aug 1, 2027 2.5 mg LillyDirect self-pay $299
  13. 13 Aug 29, 2027 2.5 mg LillyDirect self-pay $299
This is arithmetic, not a plan. Fills are spaced 28 days apart — the label's own supply length — and priced on the date each one falls, so dated price changes are already included. Your prescriber decides whether you step at all, and many people stay at a lower dose.
The label's own words (once weekly)

Initiate at 2.5 mg once weekly for 4 weeks. After 4 weeks, increase to 5 mg once weekly. The dosage may be increased in 2.5 mg increments after at least 4 weeks on the current dosage. The 2.5 mg dosage is for initiation and is not approved as a maintenance dosage. Maximum 15 mg once weekly.

Verified Aug 31, 2026 ·pi.lilly.com

Every route we can price

Verified prices outrank cheaper estimates. Reference rows inform, never win.

  1. Rank 1

    LillyDirect self-pay

    $299/mo
    • Lilly's direct channel. Vial and KwikPen at identical self-pay prices at every tier. Telehealth not included.

    Verified Sep 5, 2026 · lilly.com

  2. Rank 2

    Discount card at retail (GoodRx and similar)

    verify locally
    $299/mo
    • Dose- and pharmacy-dependent. Verify at your ZIP before relying on it.

    Verified Aug 29, 2026 · goodrx.com

  3. TrumpRx

    reference verify locally
    $299/mo
    • Starting-at price; routes you to LillyDirect pricing tiers by dose
    • Government referral site — does not sell drugs or process payments; issues coupons or routes to manufacturer DTC channels.

    Verified Sep 2, 2026 · trumprx.gov

  4. Retail list price (reference)

    reference verify locally
    $1,087/mo
    • Cited to TrumpRx, which displays $1,087 as Zepbound's list price; drugs.com stopped publishing it and now shows the LillyDirect self-pay tiers instead
    • Context anchor only — what the drug costs with no route at all. Walk-in cash at retail typically exceeds WAC.

    Verified Sep 2, 2026 · trumprx.gov

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Markdown Summary

Not your situation?

The same dose, priced the other ways it can be paid for. Most people arrive unsure which of these they are in — and it changes the answer more than anything else on this page.

Paying cash — uninsured, or not using insuranceCommercial plan that covers itCommercial plan — denied or excludedMedicare

Fighting a denial instead?

Coverage criteria and appeal routes, from the payers' own documents:

Aetna (CVS Health)Blue Cross Blue Shield Federal Employee Program (FEP)CVS CaremarkElevance Health / Anthem (CarelonRx)Express Scripts (Evernorth / Cigna)HumanaKaiser PermanenteMedicaid (state-by-state)Medicare (Part D + GLP-1 Bridge)Optum Rx (UnitedHealthcare)